Understanding GLP-1 Agonists

What are Semaglutide & Tirzepatide?

They are modified molecules our bodies make, called GLP-1 agonists. They work by increasing insulin production and lowering glucagon secretion, as well as targeting areas in the brain that regulate appetite and thirst.

  • Delays how quickly our stomachs digest foods and delays emptying, which in turn creates a feeling of fullness with smaller meal sizes than normal
  • Slows intestinal digestion which makes you feel full longer
  • Lowers blood sugar and reduces the production of sugar in the liver
  • Stimulates insulin secretion by the pancreas

Who is a candidate?

Semaglutide & Trizepatide are indicated as an adjunct to a reduced calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30kg/m2 or greater. They are also indicated in people with a BMI of at least 25kg/m2 in the presence of at least one weight-related comorbid condition such as high blood pressure, type 2 diabetes, pre-diabetes, obstructive sleep apnea, or high cholesterol. 


What are typical results people experience?

Typical weight loss with semaglutide is 15%-20% of your total body weight in one year and with Tirzepatide it’s 20-25% of your body weight in one year.


What are the most common side effects:

Nausea, diarrhea, vomiting, constipation, abdominal (stomach) pain, headache, fatigue, dyspepsia (indigestion), dizziness, abdominal distension, eructation (belching), hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence (gas buildup), gastroenteritis (an intestinal infection) and gastroesophageal reflux disease (a type of digestive disorder). 

 

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